BDBM50346585 CHEMBL1795980::S2101

SMILES NC1CC1c1cc(F)cc(F)c1OCc1ccccc1

InChI Key InChIKey=FEABGXGNJUOXAX-UHFFFAOYSA-N

Data  16 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50346585   

TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataIC50: 990nMAssay Description:The kinetic inhibition parameters of LSD1 demethylase inhibition were obtained using the peroxidase-coupled reaction method.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2013
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  610nMAssay Description:Inhibition of hexahistidine-tagged human LSD1 (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptide as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  610nMAssay Description:Inhibition of hexahistidine-tagged LSD1 (unknown origin) (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  610nMAssay Description:Inhibition of LSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  610nMAssay Description:Inhibition of LSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  880nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Riken Systems and Structural Biology Center

LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human LSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of MAO BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human MAO-B expressed in expressed in baculovirus infected BTI insect cells using tyramine as substrate by peroxidase-coupled methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human recombinant MAO-B using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of human MAO-B expressed in expressed in baculovirus infected BTI insect cells using tyramine as substrate incubated for 30 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  7.10E+4nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells using tyramine as substrate incubated for 30 mins by peroxidase-coupled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of MAO AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of human MAO-A expressed in expressed in baculovirus infected BTI insect cells using tyramine as substrate by peroxidase-coupled methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 2(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of LSD2 (unknown origin) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 2(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi: >2.50E+5nMAssay Description:Inhibition of LSD2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Key Laboratory of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of human recombinant MAO-A using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed