BDBM50443101 Cariprazine::RGH-188
SMILES CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
InChI Key InChIKey=KPWSJANDNDDRMB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 50443101
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Jiao Tong University
Curated by ChEMBL
Shanghai Jiao Tong University
Curated by ChEMBL
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of recombinant human ERG expressed in CHOK1 cells at -80 mV holding potential after 2 mins by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
Affinity DataEC50: 0.631nMAssay Description:Partial agonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as beta-arrestin2 recruitment after 20 to 22 hrs by ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
Affinity DataEC50: 0.180nMAssay Description:Partial agonist activity at human D2 receptor assessed as increase in cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Partial agonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as beta-arrestin2 recruitment after 20 to 22 hrs by ...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells co-expressing Galphai2 after 30 mins by [35S]GTPgammaS bin...More data for this Ligand-Target Pair
Affinity DataEC50: 3.5nMAssay Description:Partial agonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitmen...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment aft...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding a...More data for this Ligand-Target Pair
Affinity DataKi: 0.0850nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0850nMAssay Description:Displacement of [3H]Spiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0850nMAssay Description:Partial agonist activity at human D3 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.0960nMAssay Description:Displacement of [3H]methyl-spiperone from recombinant human D3 receptor expressed in CHO cell membranes after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 0.151nMAssay Description:Displacement of [3H]-5-HT from 5HT2B receptor in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor in HEK293 cell membranes measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.269nMAssay Description:Displacement of [3H]-SCH23390 from D3 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Displacement of [3H]Spiperone from human dopamine D3 receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Displacement of [3H]-SCH23390 from D3 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 short receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Displacement of [3H]spiperone from human D2-short receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.470nMAssay Description:Displacement of [3H]spiperone from human D2-long receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.470nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 long receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.490nMAssay Description:Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.490nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.490nMAssay Description:Displacement of [3H]-spiperone from recombinant human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.501nMAssay Description:Modulation of human D2L receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Displacement of [3H]Spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor in HEK293 cell membranes measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]spiperone from recombinant human D2L receptor expressed in CHO cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]-N-methylspiperone from D2 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scinti...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-N-methylspiperone from D2 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scinti...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]OH-DPAT from recombinant human 5-HT1A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in CHO-K1 cell membranes incubated for 60 mins by microbeta scintillation counting...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Binding affinity to 5-HT1AR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-LSD from 5HT1A receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse?Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-LSD from 5HT1A receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO cell membranes after 3 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [3H]-Ketanserin from human 5-HT2A receptor expressed in rat cortex tissue incubated for 30 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Displacement of [3H]-ketanserin from human 5HT2A receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Displacement of [3H]-pyrilamine from human H1 histamine receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair