BDBM189342 RDS1759

SMILES CCOC(=O)C(=O)CC(=O)\C=C\c1cccn1Cc1ccccc1Cl

InChI Key InChIKey=BPIOFONJRYTCQB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 189342   

TargetGag-Pol polyprotein(HIV-1)
University of Siena

LigandPNGBDBM189342(RDS1759)
Affinity DataIC50: 7.50E+3nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
University of Siena

LigandPNGBDBM189342(RDS1759)
Affinity DataIC50: 5.00E+4nMpH: 8.1Assay Description:The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2017
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
University of Siena

LigandPNGBDBM189342(RDS1759)
Affinity DataIC50: 7.40E+3nMpH: 7.8Assay Description:The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2017
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Qassim University

Curated by ChEMBL
LigandPNGBDBM189342(RDS1759)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase RNase-associated RNase H activity using RNA/DNA template-primer as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed