BDBM7966 2-(1H-imidazol-4-yl)ethan-1-amine::CHEMBL544208::CHEMBL90::Ceplene::Ergotidine::HISTAMINE DIHYDROCHLORIDE::Histamine::L-histamine::Peremin::[3H]histamine
SMILES NCCc1cnc[nH]1
InChI Key InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 114 hits for monomerid = 7966
Affinity DataEC50: 25.1nMAssay Description:Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 15.8nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rateMore data for this Ligand-Target Pair
Affinity DataEC50: 191nMAssay Description:Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...More data for this Ligand-Target Pair
Affinity DataEC50: 640nMAssay Description:Agonist activity at human recombinant histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillat...More data for this Ligand-Target Pair
Affinity DataEC50: 77nMAssay Description:Inhibition of human Histamine H3 receptor using [3H]N-alpha-methyl histamineMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Inhibition of human Histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Inhibition of human Histamine H1 receptor using [3H]pyrilamineMore data for this Ligand-Target Pair
Affinity DataEC50: 463nMAssay Description:Inhibition of human Histamine H2 receptor using [3H]tiotidineMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+3nMAssay Description:Agonist activity at human H4 receptor expressed in 293-EBNA cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 650nMAssay Description:Agonist activity at human H2 receptor expressed in 293-EBNA cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 88nMAssay Description:Agonist activity at human H3 receptor expressed in 293-EBNA cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 45nMAssay Description:Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 62nMAssay Description:Compound was evaluated for antagonistic effect on release of [3H]histamine from rat brain cortical slices with L-[3H]histidine at 0.3 uMMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rateMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataKd: 6.92E+4nMAssay Description:Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibitory activity against human Histamine H1 receptorMore data for this Ligand-Target Pair
Affinity DataKd: 1.17E+5nMAssay Description:Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 190nMAssay Description:Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 25.1nMAssay Description:Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...More data for this Ligand-Target Pair
Affinity DataEC50: 11.6nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
Affinity DataEC50: 191nMAssay Description:Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Agonist activity at human histamine H2 receptor expressed in Sf9 cells coexpressing GsalphaS protein by steady-state GTPase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 25.1nMAssay Description:Agonist activity at human histamine H3 receptor expressed in Sf9 cells coexpressing Gialpha-2-Gbeta-1-gamma-2 and RGS4 proteins protein by steady-sta...More data for this Ligand-Target Pair
Affinity DataEC50: 12.0nMAssay Description:Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at histamine H2 receptor in spontaneously beating guinea pig atriumMore data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:Agonist activity at GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Agonist activity at GsalphaS-fused guinea pig histamine H2 receptor expressed in Sf9 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 191nMAssay Description:Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12.9nMAssay Description:Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 and RGS4 by steady-state GTPase activit...More data for this Ligand-Target Pair
Affinity DataEC50: 9.12nMAssay Description:Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ...More data for this Ligand-Target Pair
TargetHistamine receptor H4(Guinea pig)
Smithkline Beecham Pharmaceuticals
Curated by PDSP Ki Database
Smithkline Beecham Pharmaceuticals
Curated by PDSP Ki Database
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H[N-alpha-methylhistamine form human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 6.31nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair