BDBM15382 8-(2,5-dimethoxybenzyl)-2-fluoro-7H-purin-6-amine::8-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-7H-purin-6-amine::CHEMBL324951::PU2::Purine-Based Inhibitor 9

SMILES COc1ccc(OC)c(Cc2nc3nc(F)nc(N)c3[nH]2)c1

InChI Key InChIKey=MWHAHELTVGJGFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15382   

TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
Vernalis (R&D)

LigandPNGBDBM15382(8-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-7H-purin-...)
Affinity DataIC50: 5.35E+4nMpH: 7.4 T: 2°CAssay Description:The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2007
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Ribotargets

Curated by ChEMBL
LigandPNGBDBM15382(8-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-7H-purin-...)
Affinity DataIC50: 5.35E+4nMAssay Description:Inhibition of ATP-ase activity in human colon tumor cell line (HCT116)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed