BDBM190652 LOX inhibitor, 13::PT171

SMILES CCCCCCc1ccn(Cc2ccccc2C)c(=O)c1

InChI Key InChIKey=ZXZSNNCDYIKZMV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 190652   

TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Yersinia pestis)
University of Wurzburg

LigandPNGBDBM190652(PT171 | LOX inhibitor, 13)
Affinity DataIC50: 5.60E+4nMAssay Description:IC50 values for the inhibition of wildtype and mutant forms of ypFabV were performed by adding varying concentrations of inhibitor dissolved in dimet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2016
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] [T276S](Yersinia pestis)
University of Wurzburg

LigandPNGBDBM190652(PT171 | LOX inhibitor, 13)
Affinity DataIC50: 6.00E+3nMAssay Description:IC50 values for the inhibition of wildtype and mutant forms of ypFabV were performed by adding varying concentrations of inhibitor dissolved in dimet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2016
Entry Details Article
PubMed
TargetArachidonate 15-lipoxygenase(Pseudomonas aeruginosa)
University of California Santa Cruz

LigandPNGBDBM190652(PT171 | LOX inhibitor, 13)
Affinity DataIC50: 520nMpH: 7.0 T: 2°CAssay Description:The one-point inhibition percentages were determined for human LOX inhibitors by following the formation of the conjugated diene product at 234 nm (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2016
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain NCTC 8325 / PS 47))
University of Wuerzburg

LigandPNGBDBM190652(PT171 | LOX inhibitor, 13)
Affinity DataKi:  11.9nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli (strain K12))
University of Wuerzburg

LigandPNGBDBM190652(PT171 | LOX inhibitor, 13)
Affinity DataKi:  95.7nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed