BDBM27500 5,6-dihydrophenanthridin-6-one::5H-Phenanthridin-6-one::5H-Phenanthridin-6-one (PTD)::6-(5H)-Phenanthridinone::CHEMBL45245::PND::Phenanthridone::phenanthridin-6(5H)-one

SMILES O=c1[nH]c2ccccc2c2ccccc12

InChI Key InChIKey=RZFVLEJOHSLEFR-UHFFFAOYSA-N

Data  10 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 27500   

TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 85nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 331nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 520nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 300nMAssay Description:The compound was tested for poly(ADP-ribose)-polymerase (PARP) inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant Poly (ADP-ribose) polymerase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 520nMAssay Description:Inhibitory concentration against purified recombinant human poly (ADP-ribose) polymerase-1 (PARP1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 350nMAssay Description:Inhibitory activity against Poly (ADP-ribose) polymerase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Bovine)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 300nMAssay Description:Inhibition of calf thymus ARTD1 assessed as incorporation of [Ade-U-14C]-NAD+ after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Konstanz

LigandPNGBDBM27500(Phenanthridone | 5H-Phenanthridin-6-one (PTD) | 5H...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed