BDBM50378647 CHEMBL1627122::PI-88

SMILES [O-]P([O-])(=O)OC[C@H]1O[C@H](O[C@H]2[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O[C@H](O[C@H]3[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O[C@H](O[C@H]4[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O[C@H](O[C@@H]5[C@@H](OS([O-])(=O)=O)O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@H]4OS([O-])(=O)=O)[C@H]3OS([O-])(=O)=O)[C@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O

InChI Key InChIKey=IPOGMIXXMPIMID-UHFFFAOYSA-A

Data  1 KI  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50378647   

TargetHeparanase(Human)
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataKd:  240nMAssay Description:Inhibition of human recombinant heparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetFibroblast growth factor 1(Human)
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataKd:  240nMAssay Description:Binding affinity to FGF1 by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetFibroblast growth factor 2(Human)
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataKd:  61nMAssay Description:Binding affinity to FGF2 by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to VEGF by surface plasmon-based solution affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetHeparanase(Human)
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataIC50: 980nMAssay Description:Inhibition of human HPSE expressed in human HREC cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataKi:  7.90nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed