BDBM50035622 (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid::CHEMBL815::DINOPROST::PGF2alpha::l-PGF2-alpha::l-Prostaglandin F2-alpha::prostaglandin F2alpha
SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
InChI Key InChIKey=PXGPLTODNUVGFL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 37 hits for monomerid = 50035622
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro binding at prostanoid IP receptor using [3H]iloprost as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)More data for this Ligand-Target Pair
Affinity DataEC50: 24.5nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)More data for this Ligand-Target Pair
Affinity DataEC50: 24.5nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:In vitro binding at EP4 human prostaglandin receptor using [3H]PGE-2 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:In vitro binding at DP human prostaglandin receptor using [3H]- PGD-2 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro binding at EP2 human prostaglandin receptor using [3H]PGE-2 as radioligandMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 2B1(Rat)
Tohoku University School of Medicine
Curated by ChEMBL
Tohoku University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 287nMAssay Description:TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:In vitro binding at EP1 human prostaglandin receptor using [3H]PGE-2 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:In vitro binding at EP3 human prostaglandin receptor using [3H]PGE-2 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 600nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%)More data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+3nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone=50%)More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+3nMAssay Description:Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=95%)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostaglandin I2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Affinity for human Prostaglandin D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 322nMAssay Description:Affinity for Prostanoid EP3 receptor expressed in CHO cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostanoid TP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Affinity for human Prostanoid FP receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Affinity for Prostanoid EP4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Prostanoid EP2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.00100nMAssay Description:In vitro binding at TP human prostaglandin receptor using [3H]SQ-29,548 as radioligandMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 2A1(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataKi: 23nMAssay Description:TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 2A1(Rat)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataKi: 45nMAssay Description:TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 2A1(Mouse)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataKi: 104nMAssay Description:TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 119nMAssay Description:Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumMore data for this Ligand-Target Pair
Affinity DataKi: 129nMAssay Description:Binding affinity for Prostanoid FP receptor of bovine corpus luteumMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneMore data for this Ligand-Target Pair