BDBM50034267 3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-(3,4,5-trimethoxybenzyl)furan-2(5H)-one::3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one::CHEMBL8981::PD-156707::PD156707

SMILES COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OC)c1)c1ccc2OCOc2c1

InChI Key InChIKey=PWIPORDFWDZCJG-UHFFFAOYSA-N

Data  8 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50034267   

TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 0.300nMAssay Description:Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 300nMAssay Description:Inhibition of [125I]ET1 binding to porcine kidney inner medulla membrane Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 780nMAssay Description:Binding affinity against human cloned Endothelin B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 780nMAssay Description:Inhibition of [125I]ET1 binding to recombinant human Endothelin B receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Endothelin B receptor mediated (ET-3) release of arachidonic acid from human cloned receptors / CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 480nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 0.300nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 0.370nMAssay Description:Binding affinity for human Endothelin A receptor expressed in LtK- cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 480nMAssay Description:Binding affinity for human endothelin B receptor expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEndothelin-1 receptor(Mouse)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin receptor type B(Mouse)
University Hospital M£Nster

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataIC50: 780nMAssay Description:Displacement of [125I]ET1 from endothelin B receptor in DBA mouse microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  0.170nMAssay Description:Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  0.920nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  139nMAssay Description:Inhibitory activity against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi:  1.42E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(PD156707 | PD-156707 | CHEMBL8981 | 3-Benzo[1,3]di...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed