BDBM50119286 3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a]azulen-9-one::CHEMBL319170::PD-146626::kb-NB165-09

SMILES COc1ccc2sc3c(SCCNC3=O)c2c1

InChI Key InChIKey=KGMSYXGSYGEHIS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50119286   

TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 82.5nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D2(Human)
University of Pittsburgh

LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 142nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
University of Pittsburgh

LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 98.5nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2011
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

LigandPNGBDBM50119286(CHEMBL319170 | PD-146626 | kb-NB165-09 | 3-Methoxy...)
Affinity DataIC50: 82.5nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed