BDBM50222709 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)benzamide::CHEMBL244488::PD-0316684::US8575391, 339

SMILES OCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F

InChI Key InChIKey=GQAZGSHVSAGDOJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50222709   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 2nMAssay Description:Inhibition assay using MEK kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 13nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human MEK-1 by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50222709(CHEMBL244488 | 3,4-difluoro-2-(2-fluoro-4-iodophen...)
Affinity DataIC50: 12nMAssay Description:Inhibition of MEK1 (unknown origin) incubated for 1 hrs in the presence of ATP by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed