BDBM50102692 4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5-dimethoxy-benzamide::4-benzyloxy-N-(1-dimethylaminocyclopentylmethyl)-3,5-dimethoxybenzamide::CHEMBL88588::ORG-25543

SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C

InChI Key InChIKey=ZCYOBMASPXQBSZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50102692   

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of human Glycine Transporter type-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Glycine Transporter type-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GlyT-1 expressed in CHO cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human GlyT-2 expressed in CHO cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human GlyT2 stably expressed in CHO cells assessed as reduction in [3H]glycine uptake incubated for 10 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human GlyT2a expressed in Xenopus laevis oocytes assessed as reduction in channel current by two-electrode voltage clamp el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50102692(ORG-25543 | 4-Benzyloxy-N-(1-dimethylamino-cyclope...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GlyT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed