BDBM50106479 CHEMBL384755::FGGFTGARKSARK::H-FGGFTGARKSARK-NH2::N/OFQ(1-13)NH2::NC(1-13)NH2::Nociceptin analogueNC(1-13)-NH2::OFQ/N::Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2

SMILES [#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O

InChI Key InChIKey=BNYHBGLVVTULJX-UHFFFAOYSA-N

Data  5 KI  1 IC50  11 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50106479   

TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  0.324nMAssay Description:Inhibition of forskolin stimulated cAMP accumulation in CHO cells stably expressing the human OP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  0.513nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of calcium mobilization by Fluo-4 AM dye based analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  8.30nMAssay Description:Agonist activity at NOP (unknown origin) expressed in HEK293 cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein acti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Rat)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  51nMAssay Description:Activity at Wistar rat NOP receptor assessed as inhibition of low-frequency electrically-stimulated vas deferens contractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Rat)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  575nMAssay Description:Activity against LFES-evoked contraction of Wistar rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Rat)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  398nMAssay Description:Activity against LFES-evoked contraction of Wistar rat vas deferens in presence of naloxoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  7.82nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  0.780nMAssay Description:Agonist activity at human NOP receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phosphorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataEC50:  1.12nMAssay Description:Efficacy for human ORL1 receptor expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataIC50: 0.353nMAssay Description:Displacement of [3H]NC from human ORL1 receptor expressing HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity to human NOP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataKi:  0.794nMAssay Description:Affinity to nociceptin receptors on mouse forebrain membranes by [3H]NC-NH2 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50106479(FGGFTGARKSARK | H-FGGFTGARKSARK-NH2 | NC(1-13)NH2 ...)
Affinity DataKi:  0.912nMAssay Description:Inhibition of [3H]NC-NH2 binding to mouse forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed