BDBM50447758 CHEBI:9287::NSC-45383::Nigrin::Rufocromomycin::Streptonigrin

SMILES COC1=C(N)C(=O)c2nc(ccc2C1=O)-c1nc(C(O)=O)c(C)c(c1N)-c1ccc(OC)c(OC)c1O

InChI Key InChIKey=PVYJZLYGTZKPJE-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50447758   

TargetDNA repair and recombination protein RAD54-like(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataEC50:  1.65E+4nMAssay Description:Inhibition of RAD54 (unknown origin) ATPase activity assessed as generation of reactive oxygen speciesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-4(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-3(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-2(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 2.61E+4nMAssay Description:Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProtein-arginine deiminase type-1(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 4.83E+4nMAssay Description:Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Zhejiang Ocean University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of PDE4 (unknown origin) by Fluopol-ABPP HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 520nMAssay Description:Inhibition of human SENP1 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human SENP2 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human SENP6 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50: 520nMAssay Description:Inhibition of SENP1 (unknown origin) using AMC-tagged SUMO1 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed