BDBM50380205 NYMPHAEOL A

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc2-[#8]-[#6@@H](-[#6]-[#6](=O)-c2c1-[#8])-c1ccc(-[#8])c(-[#8])c1

InChI Key InChIKey=JKAKKPKVTLTAPZ-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50380205   

TargetAcetylcholinesterase(Human)
Graduate School of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human erythrocyte AChE assessed as acetylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Graduate School of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of equine BChE assessed as butyrylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-pNA as substrate measured after 30 mins by spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
The Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
The Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Graduate School of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataKi:  1.20E+3nMAssay Description:Mixed type inhibition of equine BChE using butyrylthiocholine iodide as substrate by Lineweaver-Burk double-reciprocal-plot and dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Graduate School of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataKi:  8.40E+3nMAssay Description:Mixed type inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk double-reciprocal-plot and dixon plot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50380205(NYMPHAEOL A)
Affinity DataKi:  1.57E+4nMAssay Description:Noncompetitive inhibition of human neutrophil elastase using varying levels of MeOSuc-AAPV-pNA as substrate measured after 30 mins by double-reciproc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details Article
PubMed