BDBM81462 (R)-Trihexyphenidyl::(S)-Trihexyphenidyl::Benzhexol::CAS_58947-95-8::NSC_5572::TRIHEXYPHENIDYL HYDROCHLORIDE::Trihexyphenidyl

SMILES OC(CCN1CCCCC1)(C1CCCCC1)c1ccccc1

InChI Key InChIKey=HWHLPVGTWGOCJO-UHFFFAOYSA-N

Data  22 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 81462   

TargetMuscarinic acetylcholine receptor M4(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataIC50: 6.70nMAssay Description:Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataIC50: 1.30nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS radioligand using membranes from transfect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataIC50: 10nMAssay Description:Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataIC50: 26nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataIC50: 19nMAssay Description:Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  0.370nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  0.830nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Chicken)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  1.95nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor(Rabbit)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  1.95nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  2.45nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  2.95nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  5.01nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  6.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  7.08nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  13.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  15.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  123nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  269nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  490nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  676nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  1.29E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
LigandPNGBDBM81462(NSC_5572 | CAS_58947-95-8 | TRIHEXYPHENIDYL HYDROC...)
Affinity DataKi:  1.80E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed