BDBM82437 CAS_23047-25-8::Lofepramine::NSC_3947::US8629135, SW-06

SMILES CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1

InChI Key InChIKey=SAPNXPWPAUFAJU-UHFFFAOYSA-N

Data  27 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 82437   

LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Queen'S University At Kingston

US Patent
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataIC50: 2.00E+4nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
Go to US Patent

LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  2.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  5.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  67nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  67nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  330nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  360nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  460nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  880nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  2.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  2.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  3.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  4.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi:  6.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
LigandPNGBDBM82437(CAS_23047-25-8 | NSC_3947 | US8629135, SW-06 | Lof...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed