BDBM318443 NSC332398::US9624235, Compound 1

SMILES C\C(=N/Nc1cc(C)nc2cc3OCOc3cc12)c1cn(C)n(-c2ccccc2)c1=O

InChI Key InChIKey=HRKIWEVPYGRBLN-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318443   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318443(NSC332398 | US9624235, Compound 1)
Affinity DataIC50: 4.40E+3nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318443(NSC332398 | US9624235, Compound 1)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of recombinant His-6 tagged human APE1 expressed in Escherichia coli C41(DE3) using 5'-(F)-CGACTXTTGAATTGACACGCCATGTCGATCAATTCAATAGTCG-(D)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318443(NSC332398 | US9624235, Compound 1)
Affinity DataKi:  180nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent