BDBM318445 NSC332389::US9624235, Compound 3

SMILES Cc1cc(N\N=C\c2ccc3OCOc3c2)c2cc3OCOc3cc2n1

InChI Key InChIKey=BQEYNIRSTCBFEH-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318445   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318445(NSC332389 | US9624235, Compound 3)
Affinity DataIC50: 2.90E+3nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318445(NSC332389 | US9624235, Compound 3)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant His-6 tagged human APE1 expressed in Escherichia coli C41(DE3) using 5'-(F)-CGACTXTTGAATTGACACGCCATGTCGATCAATTCAATAGTCG-(D)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM318445(NSC332389 | US9624235, Compound 3)
Affinity DataKi:  190nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
In DepthDetails
US Patent