BDBM50045936 (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol::(E)-Piceatannol::3,3',4,5'-tetrahydroxystilbene::3,4,3',5'-tetrahydroxy-trans-stilbene::3,4,3',5'-tetrahydroxystillbene::4-(3,5-dihydroxystyryl)benzene-1,2-diol::4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol::4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol(Piceatannol)::4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol::4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol(Piceatannol)::CHEMBL69863::NSC-365798::US11866416, Example 8::cid_667639::piceatanol::trans-3,3',4,5'-tetrahydroxystilbene

SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1

InChI Key InChIKey=CDRPUGZCRXZLFL-UHFFFAOYSA-N

Data  10 KI  22 IC50  2 Kd  5 EC50

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50045936   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant human 5-LOX using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as dissociation constant...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 5.20E+4nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 5.20E+4nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetArginase-1(Human)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.18E+6nMAssay Description:Inhibition of recombinant human ARG1 expressed in CHO-K1 cells assessed as reduction in urea level incubated for 24 hrs by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetArginase-1(Human)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of recombinant human liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetArginase-1(Bovine)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 240nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 33(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataEC50:  1.28E+4nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetTyrosine-protein kinase Lck(Human)
Technical University of Braunschweig

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 8.18E+4nMAssay Description:Inhibition of tyrosine kinase p56-lckMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoylglutathione lyase(Human)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 760nMAssay Description:Inhibition of human N-terminal His6-tagged GLO1 expressed in baculovirus infected sf21 cells assessed as reduction in S-D-lactoylglutathione formatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p72 SykMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium dependent protein kinase(Wheat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of wheat embryo CDPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of MLCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndoribonuclease toxin MazF(Escherichia coli (strain K12))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataEC50: >9.90E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetEndoribonuclease toxin MazF(Escherichia coli (strain K12))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataEC50: >9.90E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetTyrosine-protein kinase Lck(Human)
Technical University of Braunschweig

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 6.60E+4nMAssay Description:Tested in vitro for the inhibition of protein-tyrosine kinase p56lck using angiotensin I (1.2 mM) and [gamma-32P]-ATP (50 pM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Technical University of Braunschweig

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.20E+4nMAssay Description:Binding affinity at MLCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Technical University of Braunschweig

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 8.18E+4nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Technical University of Braunschweig

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Technical University of Braunschweig

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibitory concentration against phosphorylation of angiotensin I catalyzed by protein-tyrosine kinase p56lckMore data for this Ligand-Target Pair
In DepthDetails Article

TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CD38 using 20 uM 1, N6-etheno NAD+ as substrate by continuous fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataEC50:  2.50E+4nMAssay Description:Inhibition of SYK in human lung mast cells assessed as reduction in anti-IgE-stimulated histamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of SYK in human basophils assessed as reduction in anti-IgE-stimulated histamine releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of spleen tyrosine kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of ADAMTS-5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  2.68E+3nMAssay Description:Inhibition of ADAMTS-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  4.77E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as acid mediated a...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMacrophage metalloelastase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  5.57E+3nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeutrophil collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  8.71E+3nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  1.04E+4nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetArginase-1(Bovine)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetArginase-1(Bovine)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetArginase-1(Bovine)
Univ. Bourgogne Franche-Comt�

Curated by ChEMBL
LigandPNGBDBM50045936(CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-d...)
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed