BDBM50431165 2-(3-hydroxyphenyl)-4H-chromen-4-one (2)::CHEMBL147552::NSC-22356

SMILES c1ccc2c(c1)C(=O)C=C(O2)c3cccc(c3)O

InChI Key InChIKey=ISZWRZGKEWQACU-UHFFFAOYSA-N

Data  2 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50431165   

TargetOligo-1,6-glucosidase IMA1(Baker's yeast)
Universiti Teknologi Mara

LigandPNGBDBM50431165(NSC-22356 | CHEMBL147552 | 2-(3-hydroxyphenyl)-4H-...)
Affinity DataIC50: 3.47E+4nMpH: 6.8Assay Description:The alpha-glucosidase inhibition assay had been carried out using baker's yeast alpha-glucosidase (EC 3.2.1.20) and p-nitrophenyl-alpha-D-glucopyrano...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50431165(NSC-22356 | CHEMBL147552 | 2-(3-hydroxyphenyl)-4H-...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50431165(NSC-22356 | CHEMBL147552 | 2-(3-hydroxyphenyl)-4H-...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50431165(NSC-22356 | CHEMBL147552 | 2-(3-hydroxyphenyl)-4H-...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
Birla Institute of Technology

LigandPNGBDBM50431165(NSC-22356 | CHEMBL147552 | 2-(3-hydroxyphenyl)-4H-...)
Affinity DataKi:  800nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Birla Institute of Technology

LigandPNGBDBM50431165(NSC-22356 | CHEMBL147552 | 2-(3-hydroxyphenyl)-4H-...)
Affinity DataKi:  3.02E+3nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed