BDBM92495 Malate

SMILES C([C@@H](C(=O)O)O)C(=O)O

InChI Key InChIKey=BJEPYKJPYRNKOW-UHFFFAOYSA-N

Data  6 IC50  1 Kd  1 ITC

PDB links: 107 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 92495   

TargetMethyl-accepting chemotaxis protein NahY(Pseudomonas putida (g-Proteobacteria))
Csic

LigandPNGBDBM92495(Malate)
Affinity DataKd:  8.50E+3nMT: 2°CAssay Description:Measurements were done on a VP-microcalorimeter (MicroCal, Amherst, MA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM92495(Malate)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM92495(Malate)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM92495(Malate)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human FIH expressed in H5 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProlyl hydroxylase EGLN2(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM92495(Malate)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PHD1 expressed in H5 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM92495(Malate)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PHD2 expressed in H5 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProlyl hydroxylase EGLN3(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM92495(Malate)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PHD3 expressed in H5 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 92495   

CellMethyl-accepting chemotaxis protein (McpS)(Pseudomonas putida (g-Proteobacteria))
Csic

SyringePNGBDBM92495(Malate)
ITC DataΔG°: -6.80kcal/mole −TΔS°: 16.1kcal/mole ΔH°: -22.9kcal/mole logk: 1.18E+5
T: 20.00°C 
In DepthDetails Article
PubMed