BDBM50518231 CHEMBL597248::GNF-Pf-4180::MMV006169

SMILES C(Nc1nc(Nc2ccccc2)nc2ccccc12)c1ccccc1

InChI Key InChIKey=TZQBMINEPXWUBX-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50518231   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Kasetsart University

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of rat lung PDE5 using [3H]cGMP as substrate measured after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate and measured at 12 sec interval for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense MVAT4 rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(GNF-Pf-4180 | MMV006169 | CHEMBL597248)
Affinity DataKi:  1.70E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain assessed as inhibition constant using varying levels of Z-FR-AMC as substrate by Michaelis-Menten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed