BDBM50347659 CHEMBL1802916::MK-2461

SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1

InChI Key InChIKey=JGEBLDKNWBUGRZ-UHFFFAOYSA-N

Data  32 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50347659   

TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1230More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataKd:  25nMAssay Description:Binding affinity to human recombinant His6-tagged unphosphorylated c-Met cytosolic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataKd:  4nMAssay Description:Binding affinity to human recombinant His6-tagged phosphorylated c-Met cytosolic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1235 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1234 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 50nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1365 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1235More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1234More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 640nMAssay Description:Inhibition of human RetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1365More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1349More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv11.1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 56nMAssay Description:Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 44nMAssay Description:Inhibition of human KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 2nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 7nMAssay Description:Inhibition of human RonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Flt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 24nMAssay Description:Inhibition of human MerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 39nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetFerrochelatase, mitochondrial [R115L](Human)
Technical University of Munich

LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataKd:  2.10E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 46nMAssay Description:Inhibition of human TrkAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 50nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 61nMAssay Description:Inhibition of human TrkBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 65nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 78nMAssay Description:Inhibition of human Flt4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 230nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 290nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed