BDBM50252149 (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide::(S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide::CHEMBL481931::MK-0731

SMILES CN([C@H]1CCN(C)C[C@H]1F)C(=O)N1CC(=C[C@@]1(CO)c1ccccc1)c1cc(F)ccc1F

InChI Key InChIKey=MYBGWENAVMIGMM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50252149   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 2.05E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human CENP-EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF23(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human MKLP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF3A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human Kif3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human Kif1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin-1 heavy chain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human uKHCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin heavy chain isoform 5A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human nKHCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human Kif14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF2C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-m...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cloned human MCAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed