BDBM10860 4-(aminomethyl)benzene-1-sulfonamide::CHEMBL419::MAFENIDE::aromatic sulfonamide compound 6::aromatic/heteroaromatic sulfonamide 5::hCA inhibitor, 9

SMILES NCc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=TYMRLRRVMHJFTF-UHFFFAOYSA-N

Data  159 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 165 hits for monomerid = 10860   

TargetCarbonic anhydrase 5A, mitochondrial(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibitory concentration against human cystolic isozyme V of Carbonic anhydraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration against human cystolic isozyme II of Carbonic anhydraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory constant against catalytic domain of human carbonic anhydrase XIIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  0.300nMAssay Description:Ki value against human carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant CA12 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 13(Mouse)
University of Tampere

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  41nMAssay Description:Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 13(Mouse)
University of Tampere

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  41nMAssay Description:Ki value against murine carbonic anhydrase XIIIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 7(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  75nMAssay Description:Ki value against human carbonic anhydrase VIIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Smooth cauliflower coral)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  82.5nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Smooth cauliflower coral)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  82.5nMAssay Description:Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibitory constant against human Carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibitory constant against catalytic domain of human carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibition of catalytic domain of human recombinant CA IXMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Ospedale San Lazzaro

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  103nMAssay Description:Inhibition of human recombinant CA9 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nM ΔG°:  -9.23kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Enscm/Umii/Umr-Cnrs 5635

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against human carbonic anhydrase II (CA2)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibitory constant against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase II (hCA II)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  170nMAssay Description:Inhibition of cloned isozyme, human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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