BDBM6198 AZD0530 analogue 35::M475271::Methoxy Aniline 7::N-(2-Chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1

InChI Key InChIKey=WPOXAFXHRJYEIC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6198   

LigandPNGBDBM6198(AZD0530 analogue 35 | M475271 | N-(2-Chloro-5-meth...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6198(AZD0530 analogue 35 | M475271 | N-(2-Chloro-5-meth...)
Affinity DataIC50: 670nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-RRTK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2005
Entry Details Article
PubMed
LigandPNGBDBM6198(AZD0530 analogue 35 | M475271 | N-(2-Chloro-5-meth...)
Affinity DataIC50: 10nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed
LigandPNGBDBM6198(AZD0530 analogue 35 | M475271 | N-(2-Chloro-5-meth...)
Affinity DataIC50: 670nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed
LigandPNGBDBM6198(AZD0530 analogue 35 | M475271 | N-(2-Chloro-5-meth...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant Src expressed in baculovirus infected Sf9 insect cells assessed as reduction in phosphorylation of polyglutamic acid/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed