BDBM50221066 (-)-lycorine::9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol::Amarylline::CHEMBL400092::Galanthidine::Licorine::Lycorine::Narcissine

SMILES O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@@H]([C@@H]23)[C@@H]1O

InChI Key InChIKey=XGVJWXAYKUHDOO-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50221066   

TargetCholinesterase(Horse)
Universidad Nacional De San Juan

Curated by ChEMBL
LigandPNGBDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of equine serum BuChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by DTNB-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2018
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 1.55E+5nMAssay Description:Inhibition of AChE by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Universidad Nacional De San Juan

Curated by ChEMBL
LigandPNGBDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of electric eel AChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by DTNB-based s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2018
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Universidad Nacional De San Juan

Curated by ChEMBL
LigandPNGBDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 2.13E+5nMAssay Description:Inhibition of electric eel AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetZinc finger protein GLI1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50221066(9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alp...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells coexpressing luciferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed