BDBM50029464 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid::CHEMBL292782::LY-292728

SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1

InChI Key InChIKey=DCTKEJXAVFAMFK-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50029464   

TargetLeukotriene B4 receptor 1/2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of LTB4-induced up-regulation of human neutrophil CD11b/CD18 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sultan Moulay Slimane University

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity against LTB4 receptor in human Neutrophil incubated for 10 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataKi:  0.0400nMAssay Description:LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataKi:  0.0400nMAssay Description:Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataKi:  0.470nMAssay Description:Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataKi:  0.470nMAssay Description:Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50029464(LY-292728 | 5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-f...)
Affinity DataKi:  0.470nMAssay Description:LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilMore data for this Ligand-Target Pair
In DepthDetails Article