BDBM50045092 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-9-oxo-9H-xanthene-2-carboxylic acid::5-(2-Carboxy-ethyl)-6-[6-(4-methoxy-phenyl)-hex-5-enyloxy]-9-oxo-9H-xanthene-2-carboxylic acid::CHEMBL49210::LY-210073

SMILES COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1

InChI Key InChIKey=MTTBGOLFCYOWSV-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50045092   

TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045092(LY-210073 | 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methox...)
Affinity DataIC50: 6.20nMAssay Description:In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045092(LY-210073 | 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methox...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045092(LY-210073 | 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methox...)
Affinity DataIC50: 133nMAssay Description:The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045092(LY-210073 | 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methox...)
Affinity DataKi:  5.90nMAssay Description:Inhibition constant against binding of [3H]LTB4 to human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045092(LY-210073 | 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methox...)
Affinity DataKi:  45nMAssay Description:Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article