BDBM50161646 (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine::(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL360328::LORCASERIN

SMILES C[C@H]1CNCCc2ccc(Cl)cc12

InChI Key InChIKey=XTTZERNUQAFMOF-UHFFFAOYSA-N

Data  19 KI  50 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 69 hits for monomerid = 50161646   

Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 express...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  245nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  433nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  190nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  437nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured eve...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured eve...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  248nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  158nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  79nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 express...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  1.92E+3nMAssay Description:Partial agonist activity at 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  7.60nMAssay Description:Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  437nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  433nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  245nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  248nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 h...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 h...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  11nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  478nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  943nMAssay Description:Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  3.60nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  302nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  616nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  219nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  258nMAssay Description:Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  943nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  328nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  328nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  210nMAssay Description:Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Dog)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  16.2nMAssay Description:Agonist activity at dog 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2C(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells by inositol phosphate accumulation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  258nMAssay Description:Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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