BDBM50422013 LOBELINE::Lobeline Hydrochloride

SMILES CN1[C@@H](C[C@H](O)c2ccccc2)CCC[C@H]1CC(=O)c1ccccc1

InChI Key InChIKey=MXYUKLILVYORSK-UHFFFAOYSA-N

Data  10 KI  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50422013   

TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKd:  630nMAssay Description:Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKd:  631nMAssay Description:Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataIC50: 4.47E+4nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataIC50: 1.12E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-nicotine from alpha4beta2 nicotine acetylcholine receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  5nMAssay Description:Binding affinity to alpha4beta2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  5nMAssay Description:Binding affinity to alpha4beta2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  120nMAssay Description:Inhibitory constant for cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  470nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  2.76E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  2.76E+3nMAssay Description:Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  2.76E+3nMAssay Description:Binding affinity to VMAT2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  5.46E+3nMAssay Description:Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  6.60E+3nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nicotine acetylcholine receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed