BDBM50394562 ERISMODEGIB::LDE225::N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide::Odomzo::sonidegib::sonidegib phosphate

SMILES C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)c2cccc(c2C)-c2ccc(OC(F)(F)F)cc2)cn1

InChI Key InChIKey=VZZJRYRQSPEMTK-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394562   

TargetSonic hedgehog protein(Mouse)
Jiangsu Simcere Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50394562(LDE225 | ERISMODEGIB | N-(6-((2S,6R)-2,6-dimethylm...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50394562(LDE225 | ERISMODEGIB | N-(6-((2S,6R)-2,6-dimethylm...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed