BDBM50432548 LACTACYSTIN
SMILES CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O
InChI Key InChIKey=DAQAKHDKYAWHCG-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50432548
Affinity DataIC50: 500nMAssay Description:Inhibition of beta5 subunit of immunoproteasome (unknown origin) by active-site ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of beta5i subunit of immunoproteasome (unknown origin) by active-site ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of chymotrypsin-like activity of human beta-5 subunit of 20S proteasome using Suc-LLVY-AMC as substrate by fluorometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of chymotrypsin-like activity of proteasome beta5 subunit in human MDA-MB-468 cells using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 2 hrs...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Human)
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Human)
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PGPH activity of human 26S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.96E+3nMAssay Description:Inhibition of chymotrypsin-like activity of human 26S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Human)
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PGPH activity of human 20S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Human)
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of trypsin-like activity of human 26S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Human)
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Intermed Discovery Gmbh (Imd)
Curated by ChEMBL
Affinity DataIC50: 259nMAssay Description:Inhibition of human 20S proteasomeMore data for this Ligand-Target Pair