BDBM50230993 (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid::(2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate::(R)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid::(S)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid::(S)-2-amino-5-(2-methylguanidino)pentanoic acid::(S)-2-amino-5-(3-methylguanidino)pentanoic acid::2-Amino-5-(N'-methyl-guanidino)-pentanoic acid::CHEMBL256147::L-NMMA::N omega-methyl-L-arginine::N(G)-mono-methyl-L-arginine::N(G)-monomethyl-L-arginine::N-Monomethyl-L-arginine::N-gamma-monomethyl-L-arginine::NG-Monomethyl-L-Arginine::NG-monomethyl-L-arginine acetate::Ngamma-monomethyl-L-arginine::Targinine
SMILES CNC(N)=NCCC[C@H](N)C(O)=O
InChI Key InChIKey=NTNWOCRCBQPEKQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 47 hits for monomerid = 50230993
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells pretreated 15 mins before LPS challenge measured after 20...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Concentration required for inhibition of endothelial Nitric Oxide Synthase in humanMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Concentration required for inhibition of neuronal Nitric Oxide Synthase in humanMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibitory concentration against recombinant human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOSMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of cloned (from RNA) human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cloned (from RNA) human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated fo...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Inhibition of human eNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of human nNOS expressed in Sf9 cells assessed as reduction in conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of LPS-induced iNOS activity in mouse RAW 264.7 cells assessed as inhibition of NO production pretreated with compound for 30 mins before ...More data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of human recombinant nNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Inhibition of human recombinant eNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant iNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of iNOS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of radiolabeled arginine conversion to citrulline by isomeric form of Inducible nitric oxide synthase from mouse RAW 264.7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+8nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by i-NOS from human DLD-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibitory activity against isomeric form of Neuronal nitric oxide synthase measured by citrulline assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Ability to inhibit the conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by e-NOS from HUVEC cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of neuronal nitric oxide synthase (nNOS) in miceMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of iNOS in ddY mouse peritoneal exudate cells after 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Compound was tested in vitro for inhibitory activity against inducible nitric oxide synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested in vitro for inhibitory activity against nNOS (constitutive isoform found in neurons)More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:The compound was evaluated for the inhibitory potencies using human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development
Curated by ChEMBL
Glaxo Wellcome Research and Development
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Inhibitory constant for the inhibition of human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibition of rat nNOS transfected in HEK293 cells assessed as inhibition constant in presence of NADPH by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 840nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
Affinity DataKi: 840nMAssay Description:Inhibitory constant for the inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 860nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
Affinity DataKi: 860nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair