BDBM50219348 (2S)-2-amino-4-methylpentanoic acid::(S)-(+)-leucine::(S)-leucine::CHEMBL291962::L-Leucin::L-Leuzin::L-leucine

SMILES CC(C)C[C@@H](C(=O)O)N

InChI Key InChIKey=ROHFNLRQFUQHCH-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50219348   

TargetPhospholipase A-2-activating protein(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50219348((S)-(+)-leucine | (S)-leucine | L-Leucin | L-Leuzi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PLAP by analogous luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50219348((S)-(+)-leucine | (S)-leucine | L-Leucin | L-Leuzi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TNAP by analogous luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50219348((S)-(+)-leucine | (S)-leucine | L-Leucin | L-Leuzi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of IAP by analogous luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50219348((S)-(+)-leucine | (S)-leucine | L-Leucin | L-Leuzi...)
Affinity DataIC50: 8.50E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50219348((S)-(+)-leucine | (S)-leucine | L-Leucin | L-Leuzi...)
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetProton-coupled amino acid transporter 1(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50219348((S)-(+)-leucine | (S)-leucine | L-Leucin | L-Leuzi...)
Affinity DataKi:  1.00E+8nMAssay Description:Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed