BDBM50063907 (S)-4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-2-tert-butylcarbamoyl-piperazine-1-carboxylic acid benzyl ester::CHEMBL19476::L-765314

SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1

InChI Key InChIKey=CGWOIDCAGBKOQL-UHFFFAOYSA-N

Data  7 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50063907   

TargetAlpha-1B adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 5.80E+3nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 8.80nMAssay Description:Compound was tested for the tissue binding affinity using [125I]- HEAT as radioligand to the human aorta Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 9.30nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat spleen Alpha-1B adrenergic receptor subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 9.30nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 590nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 340nMAssay Description:Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat prostate Alpha-1A adrenergic receptor subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  2nMAssay Description:Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  5.40nMAssay Description:Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  34nMAssay Description:Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  50nMAssay Description:Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  420nMAssay Description:Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1A adren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  420nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +:inactiveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50063907(L-765314 | (S)-4-(4-Amino-6,7-dimethoxy-quinazolin...)
Affinity DataKi:  500nMAssay Description:Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed