BDBM50085160 CHEMBL32842::L-674636::{4-(4-Chloro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butylsulfanyl}-acetic acid

SMILES OC(=O)CSC(CCCc1ccc(Cl)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1

InChI Key InChIKey=QEJSGEVFYKLAOJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50085160   

LigandPNGBDBM50085160(L-674636 | {4-(4-Chloro-phenyl)-1-[4-(quinolin-2-y...)
Affinity DataIC50: 122nMAssay Description:The compound was tested for the inhibition of binding of [125I]- L- 691,831 binding to 5-lipoxygenase activating protein (FLAP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50085160(L-674636 | {4-(4-Chloro-phenyl)-1-[4-(quinolin-2-y...)
Affinity DataIC50: 7nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50085160(L-674636 | {4-(4-Chloro-phenyl)-1-[4-(quinolin-2-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-LOX in indomethacin stimulated rat PMNL cells assessed as reduction in 5-LO product level incubated for 3 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed