BDBM50174022 (E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(methylsulfonyl)phenyl)vinyl)phenyl)-6-(2-(methylsulfonyl)propan-2-yl)quinoline::8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(methylsulfonyl)phenyl)vinyl)phenyl)-6-(2-(methylsulfonyl)propan-2-yl)quinoline::8-(3-methoxyphenyl)-6-(pyridin-4-ylmethyl)quinoline::CHEMBL372575::L-454560

SMILES Cc1noc(n1)C(=C\c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)\c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=YYGZHVJDHMMABU-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50174022   

TargetCytochrome P450 2C9(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 4.99E+4nMAssay Description:Displacement of [35S]MK-499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human PDE4CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 9.10nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022(L-454560 | 8-(3-methoxyphenyl)-6-(pyridin-4-ylmeth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed