BDBM18964 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]phenol::L 3372::NSC85438::US9725430, Compound 1b::US9962362, Compound 1b

SMILES CCCCc1oc2ccccc2c1C(=O)c1ccc(O)cc1

InChI Key InChIKey=ZHGKQUXXASLVQQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18964   

TargetThyroid hormone receptor alpha(Chicken)
University of Amsterdam

LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 2.00E+6nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Rat)
University of Amsterdam

LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 2.00E+6nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEyes absent homolog 3 [223-510](Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 1.01E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 1.52E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 7.14E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEyes absent homolog 3 [223-510](Mouse)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 1.01E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 1.52E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Cincinnati Childrens Hospital Medical Center

US Patent
LigandPNGBDBM18964(NSC85438 | 4-[(2-butyl-1-benzofuran-3-yl)carbonyl]...)
Affinity DataIC50: 7.14E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
In DepthDetails
US Patent