BDBM50526811 Kzr-616

SMILES COc1ccc(cc1)[C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1=CCCC1)C(=O)[C@@]1(C)CO1

InChI Key InChIKey=GHYOCDFICYLMRF-UHFFFAOYSA-N

Data  30 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50526811   

TargetProteasome subunit beta type-1(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 0.688nMAssay Description:Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 0.131nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 28nMAssay Description:Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 0.623nMAssay Description:Inhibition of 20S proteasome beta 1i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 430nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 179nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 623nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 604nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 688nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 857nMAssay Description:Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 522nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 483nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 604nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 131nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 688nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 522nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 57nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 857nMAssay Description:Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 179nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 483nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 623nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 131nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Mouse)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 57nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed