BDBM50179009 CHEMBL377937::Kuwanon L

SMILES CC1=C[C@@H]([C@H]([C@@H](C1)c1ccc(O)cc1O)C(=O)c1ccc(O)cc1O)c1c(O)ccc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)c1O

InChI Key InChIKey=ZEZOBFSLMMTYFF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50179009   

TargetGag-Pol polyprotein(HIV-1)
University of Siena

LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 990nMpH: 8.1Assay Description:The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2017
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
University of Siena

LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 570nMpH: 7.8Assay Description:The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2017
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Korea Research Institute of Bioscience and Biotechnology (Kribb)

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
Korea Research Institute of Bioscience and Biotechnology (Kribb)

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of VHR DS-PTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of recombinant HIV-1 LEDGF-dependent full length His-tagged integrase expressed in Escherichia coli BL21 (DE3) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant HIV-1 LEDGF-independent full length His-tagged integrase expressed in Escherichia coli BL21 (DE3) by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia coli using 5-GTTTTCTTTTCCCCCCTGAC-3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 990nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase activity incubated for 30 mins by multilabel counter pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant HIV-1 His-tagged LEDGF integrase preincubated for 30 mins followed by FLAG-LEDGF addition and measured after 4 hrs by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50179009(Kuwanon L | CHEMBL377937)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed