BDBM50343136 CHEMBL1770312::Kuwanon A

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c2c(cc(-[#8])cc2=O)oc1-c1ccc(-[#8])c2-[#6]=[#6]C([#6])([#6])[#8]-c12

InChI Key InChIKey=ZVMQGKDQCJOQLW-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343136   

TargetBeta-secretase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50343136(Kuwanon A | CHEMBL1770312)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50343136(Kuwanon A | CHEMBL1770312)
Affinity DataIC50: 3.52E+4nMAssay Description:Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50343136(Kuwanon A | CHEMBL1770312)
Affinity DataKi:  1.06E+4nMAssay Description:Noncompetitive inhibition of human recombinant BACE-1 by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed