BDBM14030 KT5720::hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate

SMILES [H][C@@]12C[C@@](O)(C(=O)OCCCCCC)[C@@](C)(O1)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=ZHEHVZXPFVXKEY-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14030   

TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
German Cancer Research Center

LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 56nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I](Bovine)
German Cancer Research Center

LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 1.03E+4nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M](Bovine)
German Cancer Research Center

LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 222nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [T183A](Bovine)
German Cancer Research Center

LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [E127D](Bovine)
German Cancer Research Center

LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 1.82E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 5.54E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 68nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 2.01E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 1.30E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Bovine)
German Cancer Research Center

LigandPNGBDBM14030(hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-...)
Affinity DataIC50: 1.80E+3nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed