BDBM86633 JNK-IN-8

SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1

InChI Key InChIKey=GJFCSAPFHAXMSF-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 86633   

TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK3 (unknown origin) incubated for 1 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 19nMAssay Description:Inhibition of JNK2 (unknown origin) incubated for 1 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1 (unknown origin) incubated for 1 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 46nMAssay Description:Inhibition of Nano-Luc fused JNK2 (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K5-tarcer addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 26nMAssay Description:Inhibition of Nano-Luc fused JNK1 (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K5-tarcer addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 19nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of His-tagged human recombinant JNK1 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 19nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK3 (unknown origin) after 1 hr by FRET-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.67nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 19nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 338nMAssay Description:Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 486nMAssay Description:Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK3 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 0.980nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM86633(JNK-IN-8)
Affinity DataIC50: 18.7nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed