BDBM50010283 2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione::2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione(imirestat)::CHEMBL269455::Imirestat

SMILES Fc1ccc2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2c1

InChI Key InChIKey=QCCHBHSAIQIQGO-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50010283   

TargetAldo-keto reductase family 1 member B1(Rat)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 54.7nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 27nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldehyde as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 46nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21-CodonPlus competent cells using methyl glyoxylate as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Case Western Reserve University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 45nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldeh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Case Western Reserve University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50010283(Imirestat | 2,7-difluorospiro[9H-fluorene-9,4'-(te...)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed