BDBM50273571 CHEMBL514409::Hesperadin::N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide::TCMDC-135395

SMILES CCS(=O)(=O)Nc1ccc2NC(=O)C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)c2c1

InChI Key InChIKey=SGZZQKMOFHIDKW-UHFFFAOYSA-N

Data  8 IC50  11 Kd

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50273571   

LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human AMPKA1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of aurora B kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 225nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B-A(African clawed frog)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Xenopus laevis Aurora kinase B/INCEP complex using gamma-[32P]ATP incubated for 1 hr by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Aurora kinase A/TPX2 complex using gamma-[32P]ATP incubated for 1 hr by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  149nMAssay Description:Binding affinity to human FESMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to human PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  92nMAssay Description:Binding affinity to human BRSK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Aurora-B immunoprecipitated from mitotic cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  94nMAssay Description:Binding affinity to human MSK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  31nMAssay Description:Binding affinity to human MSK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  75nMAssay Description:Binding affinity to human TYK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human PYK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFocal adhesion kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  33nMAssay Description:Binding affinity to human FAKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  77nMAssay Description:Binding affinity to human ROSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  52nMAssay Description:Binding affinity to human LTKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Aurora kinase B/INCEP complex expressed in Escherichia coli BL21 (DE3) using gamma-[32P]ATP incubated for 1 hr by autoradiographyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed