BDBM50369724 HM71224::Ly3337641::Poseltinib

SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3occc3n2)cc1

InChI Key InChIKey=LZMJNVRJMFMYQS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50369724   

TargetTyrosine-protein kinase BTK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50369724(HM71224 | Ly3337641 | Poseltinib)
Affinity DataIC50: 652nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50369724(HM71224 | Ly3337641 | Poseltinib)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50369724(HM71224 | Ly3337641 | Poseltinib)
Affinity DataIC50: 2nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50369724(HM71224 | Ly3337641 | Poseltinib)
Affinity DataIC50: 1nMAssay Description:Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEarly activation antigen CD69(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50369724(HM71224 | Ly3337641 | Poseltinib)
Affinity DataIC50: 980nMAssay Description:Inhibition of CD69 in human whole blood preincubated for 30 mins followed by anti-human IgD stimulation and measured after 18 to 22 hrs by flow cytom...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed