BDBM50260088 CHEMBL2153434::GW841819X

SMILES Cc1nnc2C(NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12

InChI Key InChIKey=TUWDLUFFAHHNEF-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50260088   

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260088(GW841819X | CHEMBL2153434)
Affinity DataIC50: 501nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human His-tagged BRD4 (1 to 477 residues) after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260088(GW841819X | CHEMBL2153434)
Affinity DataEC50:  440nMAssay Description:Inhibition of BRD4 in human HepG2 cells assessed as upregulation of ApoA1 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed